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What is Orlistat?
Orlistat (the generic version of Xenical) is a proven weight loss medication licensed for supply in the UK. There are 2 different strengths available.
60mg available as Alli 60mg Hard Capsules and Orlos 60mg Hard Capsules, can be bought over the counter, 120mg is prescription only but available through the consultation service here at SimplyMeds Online either as Orlistat or Xenical 120mg Capsules.
Orlistat was given its legal license for sale in 2009 by the European Medicines Agency. It is a safer alternative to the older appetite suppressing medicines that used to be available on the market. Older medicines such as Sibutramine were loosely based on amphetamines and thus presented a danger to the patient using them. Patients would often experience many unpleasant side effects as well as other long term health problems. Orlistat works via a completely different route and doesn’t present the same dangers to the patient.
Orlistat also works in a different way to the newer weight loss injections that have come to market, including Wegovy and Saxenda, known as GLP-1 agonists that mimicking natural effects of hormones.
How Does Orlistat Work?
Orlistat 120mg capsules are the generic version of the Roche product, Xenical. Roche is no longer the only license holder for the production of Orlistat and thus Xenical is no longer the only prescription product available for weight loss. This has resulted in a significant price reduction of available Orlistat.
Orlistat works by preventing about a third of the fat from the food you eat from being digested. The undigested fat is not absorbed, and is passed out with your faeces. Combined with a balanced diet and exercise it can be a safe and effective way to help you with your weight loss goals.
In one study, up to 54% of patients trialed lost at least 5% of their body fat within 3 months. With a further 35% losing 10% within 6 months. (US FDA).
The active ingredient attaches to the enzymes in your small intestine (lipases) and blocks those from breaking down some of the fat you have eaten during your meal. The undigested fat cannot be absorbed and leaves your body when you go to the toilet.
How Effective are the Capsules?
Clinical studies have found that, if used correctly, Orlistat helps patients lose 50% more weight loss compared to dieting alone. As Orlistat works directly to stop dietary fat absorption, results are usually seen quite soon after starting treatment, although this is very heavily dependent on the individual’s lifestyle and diet. it is recommended that the treatment be taken for at least 12 weeks to assess the rate of weight loss and whether the treatment is suitable for a longer period of time. Patients should achieve at least a 5% reduction in their overall weight within 12 weeks. As the capsules block fat absorption, Orlistat use can also result in a slight decrease in a patient’s serum cholesterol.
Who can use Orlistat?
The treatment can be used by patients who have a BMI (kg/m2) greater than 30 or over 28 if you also suffer from other weight related conditions such as high blood pressure or diabetes (to use the NHS BMI calculator please CLICK HERE). Should your BMI drop below this point, you should consider another more suitable method for weight loss in the longer term.
Orlistat (Xenical) is usually recommended if you have made a significant effort to lose weight through diet, exercise or changing your lifestyle.
Orlistat is not recommended for use by pregnant or breastfeeding women.
What Vitamins Help Weight Loss?
Several vitamins aid weight loss by supporting metabolic functions and overall health. These include Vitamin C, K and E. Vitamin C encourages the body to create carnitine, which helps the body convert fat into energy. Vitamin K is important for maintaining a healthy metabolism and Vitamin E is an antioxidant known to support weight loss and protect cells.
Taking weight loss vitamins or supplements alongside a healthy diet and exercise can help with weight loss success.
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